Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thrombospondin expression in myofibers stabilizes muscle membranes

26 Sept 2016

Abstract excerpt

Skeletal muscle is highly sensitive to mutations in genes that participate in membrane stability and cellular attachment, which often leads to muscular dystrophy. Here we show that Thrombospondin-4 (Thbs4) regulates skeletal muscle integrity and its susceptibility to muscular dystrophy through organization of membrane attachment complexes. Loss of the Thbs4 gene causes spontaneous dystrophic changes with aging...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Muscle Physiology and Disorders
Share to Silk-based biomaterials and applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27669143
DOI: 10.7554/elife.17589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thrombospondin expression in myofibers stabilizes muscle membranesPMID 27669143Read ↗

Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions.Semantic proximity Read ↗

Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy.Semantic proximity Read ↗

The thrombospondins.Semantic proximity Read ↗

Dystrophin and its isoforms.Semantic proximity Read ↗

Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathySemantic proximity Read ↗

Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy.Semantic proximity Read ↗

AlphaPS2 integrin-mediated muscle attachment in Drosophila requires the ECM protein Thrombospondin.Semantic proximity Read ↗

Costamere proteins and their involvement in myopathic processes.Semantic proximity Read ↗

<i>Drosophila</i> Short stop as a paradigm for the role and regulation of spectraplakinsSemantic proximity Read ↗

Phenotypic Switching of Vascular Smooth Muscle Cells in Duchenne Muscular DystrophySemantic proximity Read ↗

Muscle genome-wide expression profiling during disease evolution in mdx miceSemantic proximity Read ↗

Repairing the tears: dysferlin in muscle membrane repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.