Article
The C-terminal unique region of desmoglein 2 inhibits its internalization via tail-tail interactions.
The Journal of cell biology - 12 Nov 2012
Chen Jing, Nekrasova Oxana E, Patel Dipal M, Klessner Jodi L, Godsel Lisa M, Koetsier Jennifer L, Amargo Evangeline V, Desai Bhushan V, Green Kathleen J
Abstract excerpt
Desmosomal cadherins, desmogleins (Dsgs) and desmocollins, make up the adhesive core of intercellular junctions called desmosomes. A critical determinant of epithelial adhesive strength is the level and organization of desmosomal cadherins on the cell surface. The Dsg subclass of desmosomal cadherins contains a C-terminal unique region (Dsg unique region [DUR]) with unknown function. In this paper, we show that...
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