Article

The membrane curvature inducing REEP1 proteins generate a novel ER-derived vesicular compartment

2023-12-19

Abstract excerpt

The endoplasmic reticulum (ER) is shaped by abundant, membrane curvature-generating proteins that include the REEP family member REEP5. The REEP1 subfamily, consisting of REEP1-4 in mammals, differs in abundance and topology from REEP5. Mutations in REEP1 and REEP2 cause Hereditary Spastic Paraplegia, but REEP1-4’s function remains enigmatic. Here we show that the REEP1 proteins reside in a novel vesicular compart...

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Literature Corpus work: 35553f31-aab3-5902-a3f7-352b79505cf8
DOI: 10.1101/2023.12.19.572386

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