Article
Mutations of PIK3CA in gastric adenocarcinoma.
BMC cancer - 23 Mar 2005
Li Vivian Sze Wing, Wong Chi Wai, Chan Tsun Leung, Chan Agnes Sze Wah, Zhao Wei, Chu Kent-Man, So Samuel, Chen Xin, Yuen Siu Tsan, Leung Suet Yi
Abstract excerpt
BACKGROUND: Activation of the phosphatidylinositol 3-kinase (PI3K) through mutational inactivation of PTEN tumour suppressor gene is common in diverse cancer types, but rarely reported in gastric cancer. Recently, mutations in PIK3CA, which encodes the p110alpha catalytic subunit of PI3K, have been identified in various human cancers, including 3 of 12 gastric cancers. Eighty percent of these reported mutations...
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