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Threonine 454 phosphorylation in Grainyhead-like 3 is important for its function and regulation by the p38 MAPK pathway.

Biochimica et biophysica acta. Molecular cell research - 1 Jul 2018

Krzywinska Ewa, Zorawski Marek Dominick, Taracha Agnieszka, Kotarba Grzegorz, Kikulska Agnieszka, Mlacki Michal, Kwiatkowska Katarzyna, Wilanowski Tomasz

Abstract excerpt

The mammalian Grainyhead-like 3 (GRHL3) transcription factor is essential for epithelial development and plays a protective role against squamous cell carcinoma of the skin and of the oral cavity. A single nucleotide polymorphism (SNP) in GRHL3, rs141193530 (p.P455A), is associated with non-melanoma skin cancer in human patients. Moreover, it is known that this SNP, as well as another variant, rs41268753...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29702134
DOI: 10.1016/j.bbamcr.2018.04.010

Genes

GRHL3

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