Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The MKK-Dependent Phosphorylation of p38α Is Augmented by Arginine Methylation on Arg49/Arg149 during Erythroid Differentiation.

International journal of molecular sciences - 17 May 2020

Liu Mei-Yin, Hua Wei-Kai, Chen Chi-Ju, Lin Wey-Jinq

Abstract excerpt

The activation of p38 mitogen-activated protein kinases (MAPKs) through a phosphorylation cascade is the canonical mode of regulation. Here, we report a novel activation mechanism for p38α. We show that Arg49 and Arg149 of p38α are methylated by protein arginine methyltransferase 1 (PRMT1). The non-methylation mutations of Lys49/Lys149 abolish the promotive effect of p38α on erythroid differentiation. MAPK kinase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginine
Share to Erythropoiesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to MAP Kinase Signaling System

Share to Mass Spectrometry

Share to Methylation

Share to p38 Mitogen-Activated Protein Kinases

Share to Protein-Arginine N-Methyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 32429593
DOI: 10.3390/ijms21103546
PMCID: PMC7278938

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The MKK-Dependent Phosphorylation of p38α Is Augmented by Arginine Methylation on Arg49/Arg149 during Erythroid Differentiation.PMID 32429593Read ↗

Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation.Semantic proximity Read ↗

PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis.Semantic proximity Read ↗

Regulation of the ring finger E3 ligase Siah2 by p38 MAPK.Semantic proximity Read ↗

p38alpha is active in vitro and in vivo when monophosphorylated at threonine 180.Semantic proximity Read ↗

Threonine 454 phosphorylation in Grainyhead-like 3 is important for its function and regulation by the p38 MAPK pathway.Semantic proximity Read ↗

PRMT5-Mediated Methylation of NF-κB p65 at Arg174 Is Required for Endothelial CXCL11 Gene Induction in Response to TNF-α and IFN-γ Costimulation.Semantic proximity Read ↗

PRMT5-mediated regulatory arginine methylation of RIPK3Semantic proximity Read ↗

Are STATS arginine-methylated?Semantic proximity Read ↗

Protein arginine methyltransferase 1 regulates herpes simplex virus replication through ICP27 RGG-box methylation.Semantic proximity Read ↗

p38 MAP kinase drives the expression of mast cell-derived IL-9 via activation of the transcription factor GATA-1.Semantic proximity Read ↗

Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif.Semantic proximity Read ↗

A remodeled protein arginine methyltransferase 1 (PRMT1) generates symmetric dimethylarginine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.