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Article

Novel GRHL3 Variants in a South African Cohort With Cleft Lip and Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association - 1 Sept 2022

Naicker Thirona, Adeleke Chinyere C, Alade Azeez, Mossey Peter A, Awotoye Waheed A, Busch Tamara D, Li Mary, Olotu Joy, Gowans Lord J J, Aldous Colleen, Butali Azeez

Abstract excerpt

OBJECTIVE: The etiology of cleft palate (CP) is poorly understood compared with that of cleft lip with or without palate (CL ± P). Recently, variants in Grainyhead like transcription factor 3 (GRHL3) were reported to be associated with a risk for CP in European and some African populations including Nigeria, Ghana, and Ethiopia. In order to identify genetic variants that may further explain the etiology of CP, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34459660
DOI: 10.1177/10556656211038453
PMCID: PMC9790085

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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