Article
Mitotic abnormalities precede microsatellite instability in lynch syndrome-associated colorectal tumourigenesis.
EBioMedicine - 1 May 2024
Pussila Marjaana, Laiho Aleksi, Törönen Petri, Björkbacka Pauliina, Nykänen Sonja, Pylvänäinen Kirsi, Holm Liisa, Mecklin Jukka-Pekka, Renkonen-Sinisalo Laura, Lehtonen Taru, Lepistö Anna, Linden Jere, Mäki-Nevala Satu, Peltomäki Päivi, Nyström Minna
Abstract excerpt
BACKGROUND: Lynch syndrome (LS) is one of the most common hereditary cancer syndromes worldwide. Dominantly inherited mutation in one of four DNA mismatch repair genes combined with somatic events leads to mismatch repair deficiency and microsatellite instability (MSI) in tumours. Due to a high lifetime risk of cancer, regular surveillance plays a key role in cancer prevention; yet the observation of frequent...
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