A prospective study of the impact of AGTR1 A1166C on the effects of candesartan in patients with heart failure.

doi:10.2217/pgs-2018-0004

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Article

A prospective study of the impact of AGTR1 A1166C on the effects of candesartan in patients with heart failure.

Pharmacogenomics - 1 May 2018

de Denus Simon, Dubé Marie-Pierre, Fouodjio René, Huynh Thao, LeBlanc Marie-Hélène, Lepage Serge, Sheppard Richard, Giannetti Nadia, Lavoie Joël, Mansour Asmaa, Provost Sylvie, Normand Valérie, Mongrain Ian, Langlois Mathieu, O'Meara Eileen, Ducharme Anique, Racine Normand, Guertin Marie-Claude, Turgeon Jacques, Phillips Michael S, Rouleau Jean-Lucien, Tardif Jean-Claude, White Michel

Abstract excerpt

AIM: To evaluate the impact of AGTR1 A1166C (rs5186) on the response to candesartan in patients with heart failure. MATERIALS & METHODS: Prospective, multicentre, open-label study. We studied 299 symptomatic patients with heart failure presenting a left ventricular ejection fraction ≤40%. RESULTS: Reductions in the primary end points of natriuretic peptides were not significantly associated with AGTR1 A1166C....

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PMID: 29701105
DOI: 10.2217/pgs-2018-0004

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AGTR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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