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Article

Association of left ventricular mass with the AGTR1 A1166C polymorphism.

American journal of hypertension - 1 Apr 2012

Jin Yu, Kuznetsova Tatiana, Thijs Lut, Schmitz Boris, Liu Yanping, Asayama Kei, Brand Stefan-Martin, Heymans Stephane, Brand Eva, Fagard Robert, Staessen Jan A

Abstract excerpt

BACKGROUND: The A1166C polymorphism is located within the microRNA-155 binding site of the human angiotensin II (Ang II) type-1 receptor (AGTR1) gene. The C allele interferes with the base-pairing complementariness between AGTR1 mRNA and microRNA-155 and thereby increases AGTR1 protein expression in vitro. We hypothesized that left ventricular (LV) mass is associated with the AGTR1 A1166C polymorphism. METHODS:...

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Identifiers

PMID: 22237156
DOI: 10.1038/ajh.2011.244

Genes

AGTR1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Association of left ventricular mass with the AGTR1 A1166C polymorphism.PMID 22237156Read ↗

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Role of angiotensin II type I (AT1 A1166C) receptor polymorphism in susceptibility of left ventricular dysfunction.Semantic proximity Read ↗

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Angiotensin receptor type 1 single nucleotide polymorphism 1166A/C is associated with malignant arrhythmias and altered circulating miR-155 levels in patients with chronic heart failure.Semantic proximity Read ↗

AT1 receptor A/C1166 polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy.Semantic proximity Read ↗

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Angiotensin II type 1 receptor A/C1166 polymorphism. Relationships with blood pressure and cardiovascular structure.Semantic proximity Read ↗

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Polymorphisms in the angiotensinogen and angiotensin II type 1 receptor gene are related to change in left ventricular mass during antihypertensive treatment: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial.Semantic proximity Read ↗

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