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Article

Lack of association between the MDM2-SNP309 polymorphism and breast cancer risk.

Anticancer research - 1 Jan 2000

Petenkaya Aslihan, Bozkurt Betul, Akilli-Ozturk Ozlem, Kaya Hatice Seda, Gur-Dedeoglu Bala, Yulug Isik G

Abstract excerpt

BACKGROUND: A T-to-G polymorphism (SNP309) at the promoter region of MDM2 has been recently reported to extend the Sp1 binding site that positively regulates the MDM2 transcription level and consequently, its expression level. MDM2 is the negative regulator of p53 tumor suppressor protein and elevated levels of MDM2 hamper the stress response driven by the p53 pathway. Whether MDM2-SNP309 was associated with...

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Identifiers

PMID: 17214373

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lack of association between the MDM2-SNP309 polymorphism and breast cancer risk.PMID 17214373Read ↗

Significant Association of the MDM2 T309G Polymorphism with Breast Cancer Risk in a Turkish PopulationSemantic proximity Read ↗

MDM2SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk.Semantic proximity Read ↗

Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population.Semantic proximity Read ↗

No association between the MDM2 -309 T/G promoter polymorphism and breast cancer in African-Americans or Whites.Semantic proximity Read ↗

MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies.Semantic proximity Read ↗

Assessment of TP53 Polymorphisms and MDM2 SNP309 in Premenopausal Breast Cancer Risk.Semantic proximity Read ↗

Association of polymorphism in MDM-2 and p53 genes with breast cancer risk in Indian women.Semantic proximity Read ↗

A case-control study on the SNP309T → G and 40-bp Del1518 of the MDM2 gene and a systematic review for MDM2 polymorphisms in the patients with breast cancer.Semantic proximity Read ↗

Association of breast cancer outcome with status of p53 and MDM2 SNP309.Semantic proximity Read ↗

MDM2 SNP309 polymorphism and breast cancer risk: a meta-analysis.Semantic proximity Read ↗

No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer.Semantic proximity Read ↗

Differential effects of MDM2 SNP309 polymorphism on breast cancer risk along with race: a meta-analysis.Semantic proximity Read ↗

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