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Inactivation of tesA Reduces Cell Wall Lipid Production and Increases Drug Susceptibility in Mycobacteria

19 May 2011

Abstract excerpt

Phthiocerol dimycocerosates (PDIMs) and phenolic glycolipids (PGLs) are structurally related lipids noncovalently bound to the outer cell wall layer of Mycobacterium tuberculosis, Mycobacterium leprae, and several opportunistic mycobacterial human pathogens. PDIMs and PGLs are important effectors of virulence. Elucidation of the biosynthesis of these complex lipids will not only expand our understanding of...

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Carbohydrate Chemistry and Synthesis
Microbial Natural Products and Biosynthesis
Mycobacterium research and diagnosis

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21592957
DOI: 10.1074/jbc.m111.247601

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