Article
Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice.
Gastroenterology - 1 Sept 2012
Meng Fanli, Wang Kai, Aoyama Tomonori, Grivennikov Sergei I, Paik YongHan, Scholten David, Cong Min, Iwaisako Keiko, Liu Xiao, Zhang Mingjun, Österreicher Christoph H, Stickel Felix, Ley Klaus, Brenner David A, Kisseleva Tatiana
Abstract excerpt
BACKGROUND & AIMS: Interleukin (IL)-17 signaling has been implicated in lung and skin fibrosis. We examined the role of IL-17 signaling in the pathogenesis of liver fibrosis in mice. METHODS: Using cholestatic and hepatotoxic models of liver injury, we compared the development of liver fibrosis in wild-type mice with that of IL-17RA(-/-) mice and of bone marrow chimeric mice devoid of IL-17 signaling in immune...
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