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Article

Loss of BOK Has a Minor Impact on Acetaminophen Overdose-Induced Liver Damage in Mice.

International journal of molecular sciences - 23 Mar 2021

Naim Samara, Fernandez-Marrero Yuniel, de Brot Simone, Bachmann Daniel, Kaufmann Thomas

Abstract excerpt

Acetaminophen (APAP) is one of the most commonly used analgesic and anti-pyretic drugs, and APAP intoxication is one of the main reasons for liver transplantation following liver failure in the Western world. While APAP poisoning ultimately leads to liver necrosis, various programmed cell death modalities have been implicated, including ER stress-triggered apoptosis. The BCL-2 family member BOK (BCL-2-related...

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Share to Acetaminophen
Share to Chemical and Drug Induced Liver Injury

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2E1

Share to Endoplasmic Reticulum Stress

Share to Genes, p53

Share to Proto-Oncogene Proteins c-bcl-2

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Source

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Identifiers

PMID: 33807047
DOI: 10.3390/ijms22063281
PMCID: PMC8004760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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