Article
Phenotypic pleiotropy of missense variants in human B cell confinement receptor P2RY8.
Cell genomics - 12 Nov 2025
LaFlam Taylor N, Billesbølle Christian B, Dinh Tuan, Wolfreys Finn D, Lu Erick, Matteson Tomas, An Jinping, Xu Ying, Singhal Arushi, Brandes Nadav, Ntranos Vasilis, Manglik Aashish, Cyster Jason G, Ye Chun Jimmie
Abstract excerpt
Missense variants can have pleiotropic effects on protein function, and predicting these effects can be difficult. We performed near-saturation deep mutational scanning of P2RY8, a G protein-coupled receptor that promotes germinal center B cell confinement. We assayed the effect of each variant on surface expression, migration, and proliferation. We delineated variants that affected both expression and function,...
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