Article
Sequencing Directly from Clinical Specimens Reveals Genetic Variations in HCMV-Encoded Chemokine Receptor US28 That May Influence Antibody Levels and Interactions with Human Chemokines.
Microbiology spectrum - 31 Oct 2021
Waters Shelley, Agostino Mark, Lee Silvia, Ariyanto Ibnu, Kresoje Nina, Leary Shay, Munyard Kylie, Gaudieri Silvana, Gaff Jessica, Irish Ashley, Keil Anthony D, Price Patricia, Allcock Richard J N
Abstract excerpt
Human cytomegalovirus (HCMV) is a beta-herpesvirus carried by ∼80% of the world's population. Acute infections are asymptomatic in healthy individuals but generate diverse syndromes in neonates, solid organ transplant recipients, and HIV-infected individuals. The HCMV gene US28 encodes a homolog of a human chemokine receptor that is able to bind several chemokines and HIV gp120. Deep sequencing technologies were...
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