Article
New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status.
Brain tumor pathology - 1 Jul 2011
Shibahara Ichiyo, Sonoda Yukihiko, Kanamori Masayuki, Saito Ryuta, Kumabe Toshihiro, Tominaga Teiji
Abstract excerpt
In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains...
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