Article
IDH1 and IDH2 mutations in gliomas.
Current neurology and neuroscience reports - 1 May 2013
Cohen Adam L, Holmen Sheri L, Colman Howard
Abstract excerpt
Mutations in isocitrate dehydrogenase (IDH) 1 and 2, originally discovered in 2008, occur in the vast majority of low-grade gliomas and secondary high-grade gliomas. These mutations, which occur early in gliomagenesis, change the function of the enzymes, causing them to produce 2-hydroxyglutarate, a possible oncometabolite, and to not produce NADPH. IDH mutations are oncogenic, although whether the mechanism is...
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