Regime shifts driven by dynamic correlations in gene expression noise.

Abstract excerpt

Gene expression is a noisy process that leads to regime shifts between alternative steady states among individual living cells, inducing phenotypic variability. The effects of white noise on the regime shift in bistable systems have been well characterized, however little is known about such effects of colored noise (noise with nonzero correlation time). Here, we show that noise correlation time, by considering a...

Topics

• Computer Simulation
• Gene Expression
• Gene Regulatory Networks
• Humans
• Models, Genetic
• Phenotype
• Proteins
• Stochastic Processes
• Time Factors