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Article

ADP-ribosyltransferases Parp1 and Parp7 safeguard pluripotency of ES cells.

Nucleic acids research - 1 Aug 2014

Roper Stephen J, Chrysanthou Stephanie, Senner Claire E, Sienerth Arnold, Gnan Stefano, Murray Alexander, Masutani Mitsuko, Latos Paulina, Hemberger Myriam

Abstract excerpt

Embryonic stem (ES) cells are in a dynamic equilibrium of distinct functional states, characterized by the heterogeneous expression of critical pluripotency factors and regulated by a spectrum of reversible histone modifications. Maintenance of this equilibrium is a hallmark of pluripotency. Here we find that the ADP-ribosyltransferases Parp1 and Parp7 play a critical role in safeguarding this state by occupying...

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Identifiers

PMID: 25034692
DOI: 10.1093/nar/gku591
PMCID: PMC4132717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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