Article
The rate of meiotic gene conversion varies by sex and age.
Nature genetics - 1 Nov 2016
Halldorsson Bjarni V, Hardarson Marteinn T, Kehr Birte, Styrkarsdottir Unnur, Gylfason Arnaldur, Thorleifsson Gudmar, Zink Florian, Jonasdottir Adalbjorg, Jonasdottir Aslaug, Sulem Patrick, Masson Gisli, Thorsteinsdottir Unnur, Helgason Agnar, Kong Augustine, Gudbjartsson Daniel F, Stefansson Kari
Abstract excerpt
Meiotic recombination involves a combination of gene conversion and crossover events that, along with mutations, produce germline genetic diversity. Here we report the discovery of 3,176 SNP and 61 indel gene conversions. Our estimate of the non-crossover (NCO) gene conversion rate (G) is 7.0 for SNPs and 5.8 for indels per megabase per generation, and the GC bias is 67.6%. For indels, we demonstrate a 65.6%...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.