Article
Quantitative assessment of intragenic receptor tyrosine kinase deletions in primary glioblastomas: their prevalence and molecular correlates.
Acta neuropathologica - 1 May 2014
Kastenhuber Edward R, Huse Jason T, Berman Samuel H, Pedraza Alicia, Zhang Jianan, Suehara Yoshiyuki, Viale Agnes, Cavatore Magali, Heguy Adriana, Szerlip Nicholas, Ladanyi Marc, Brennan Cameron W
Abstract excerpt
Intragenic deletion is the most common form of activating mutation among receptor tyrosine kinases (RTK) in glioblastoma. However, these events are not detected by conventional DNA sequencing methods commonly utilized for tumor genotyping. To comprehensively assess the frequency, distribution, and expression levels of common RTK deletion mutants in glioblastoma, we analyzed RNA from a set of 192 glioblastoma...
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