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Article

Distribution and favorable prognostic implication of genomic EGFR alterations in IDH-wildtype glioblastoma.

Cancer medicine - 1 Jan 2023

Higa Nayuta, Akahane Toshiaki, Hamada Taiji, Yonezawa Hajime, Uchida Hiroyuki, Makino Ryutaro, Watanabe Shoji, Takajo Tomoko, Yokoyama Seiya, Kirishima Mari, Matsuo Kei, Fujio Shingo, Hanaya Ryosuke, Tanimoto Akihide, Yoshimoto Koji

Abstract excerpt

BACKGROUND: We aimed to evaluate the mutation profile, transcriptional variants, and prognostic impact of the epidermal growth factor receptor (EGFR) gene in isocitrate dehydrogenase (IDH)-wildtype glioblastomas (GBMs). METHODS: We sequenced EGFR, evaluated the EGFR splicing profile using a next-generation sequencing oncopanel, and analyzed the outcomes in 138 grade IV IDH-wildtype GBM cases. RESULTS: EGFR...

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Identifiers

PMID: 35695190
DOI: 10.1002/cam4.4939
PMCID: PMC9844636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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