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Article

Differential effects of 14-3-3 dimers on Tau phosphorylation, stability and toxicity in vivo.

Human molecular genetics - 1 Jul 2018

Papanikolopoulou Katerina, Grammenoudi Sofia, Samiotaki Martina, Skoulakis Efthimios M C

Abstract excerpt

Neurodegenerative dementias collectively known as Tauopathies involve aberrant phosphorylation and aggregation of the neuronal protein Tau. The largely neuronal 14-3-3 proteins are also elevated in the central nervous system (CNS) and cerebrospinal fluid of Tauopathy patients, suggesting functional linkage. We use the simplicity and genetic facility of the Drosophila system to investigate in vivo whether 14-3-3s...

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Identifiers

PMID: 29659825
DOI: 10.1093/hmg/ddy129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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