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<i>Drosophila</i> models of human tauopathies indicate that Tau protein toxicity <i>in vivo</i> is mediated by soluble cytosolic phosphorylated forms of the protein

27 Feb 2010

Abstract excerpt

Tau is a neuronal microtubule-associated protein involved in microtubules assembly and stabilization. Tauopathies, including Alzheimer's disease and fronto-temporal dementia with parkinsonism linked to chromosome 17, are a group of neurodegenerative disorders characterized by the presence of intraneuronal filamentous inclusions of abnormally and hyperphosphorylated Tau. Currently, the molecular mechanisms...

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PMID: 20193038
DOI: 10.1111/j.1471-4159.2010.06663.x

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