Article
Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2015
Joo Yuyoung, Schumacher Benjamin, Landrieu Isabelle, Bartel Maria, Smet-Nocca Caroline, Jang Ahram, Choi Hee Soon, Jeon Noo Li, Chang Keun-A, Kim Hye-Sun, Ottmann Christian, Suh Yoo-Hun
Abstract excerpt
14-3-3 proteins act as adapters that exert their function by interacting with their various protein partners. 14-3-3 proteins have been implicated in a variety of human diseases including neurodegenerative diseases. 14-3-3 proteins have recently been reported to be abundant in the neurofibrillary tangles (NFTs) observed inside the neurons of brains affected by Alzheimer's disease (AD). These NFTs are mainly...
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