Article
A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer's disease in Hong Kong Chinese population.
Neurobiology of aging - 1 Aug 2018
Wang Binbin, Bao Suying, Zhang Zhigang, Zhou Xueya, Wang Jing, Fan Yanhui, Zhang Yan, Li Yan, Chen Luhua, Jia Yizhen, Li Jiang, Li Miaoxin, Zheng Wenhua, Mu Nan, Wang Liqiu, Yu Zhe, Wong Dana S M, Zhang Yalun, Kwan Joseph, Ka-Fung Mak Henry, Ambalavanan Amirthagowri, Zhou Sirui, Cai Wangwei, Zheng Jin, Huang Shishu, Rouleau Guy A, Yang Wanling, Rogaeva Ekaterina, Ma Xu, St George-Hyslop Peter, Chu Leung Wing, Song You-Qiang
Abstract excerpt
Alzheimer's disease (AD) is the most common neurodegenerative disorders in the elderly. To identify rare genetic factors other than apolipoprotein E ɛ4 allele (ApoE ɛ4) contributing to the pathogenesis of late-onset AD (LOAD), we conducted a whole-exome analysis of 246 ApoE ɛ4-negative LOAD cases and 172 matched controls in Hong Kong Chinese population. LOAD patients showed a significantly higher burden of rare...
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