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Article

Whole-genome sequencing reveals novel ethnicity-specific rare variants associated with Alzheimer's disease.

Molecular psychiatry - 1 May 2022

Shigemizu Daichi, Asanomi Yuya, Akiyama Shintaro, Mitsumori Risa, Niida Shumpei, Ozaki Kouichi

Abstract excerpt

Alzheimer's disease (AD) is the most common multifactorial neurodegenerative disease among elderly people. Genome-wide association studies (GWAS) have been highly successful in identifying genetic risk factors. However, GWAS investigate common variants, which tend to have small effect sizes, and rare variants with potentially larger phenotypic effects have not been sufficiently investigated. Whole-genome...

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Identifiers

PMID: 35264725
DOI: 10.1038/s41380-022-01483-0
PMCID: PMC9135624

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