Article
Influenza A virus hemagglutinin antibody escape promotes neuraminidase antigenic variation and drug resistance.
PloS one - 22 Feb 2011
Hensley Scott E, Das Suman R, Gibbs James S, Bailey Adam L, Schmidt Loren M, Bennink Jack R, Yewdell Jonathan W
Abstract excerpt
Drugs inhibiting the influenza A virus (IAV) neuraminidase (NA) are the cornerstone of anti-IAV chemotherapy and prophylaxis in man. Drug-resistant mutations in NA arise frequently in human isolates, limiting the therapeutic application of NA inhibitors. Here, we show that antibody-driven antigenic variation in one domain of the H1 hemagglutinin Sa site leads to compensatory mutations in NA, resulting in NA...
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