Article

A Heart Disease-Associated TSPO Variant Alters Transmembrane Helix Dynamics

2026-04-13

Abstract excerpt

The 18-kDa translocator protein TSPO is an outer mitochondrial membrane protein involved in cholesterol transport, stress response, and cellular metabolism. Although its five-helix architecture is conserved across species, the structural and dynamic features of human TSPO remain unresolved. Using solution NMR spectroscopy, we characterize the conformational dynamics of human TSPO in complex with a third-generation...

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Literature Corpus work: 00f96b1f-ce3f-5bae-9ee8-55a9fe9f2d1c
DOI: 10.64898/2026.04.10.717289

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