Computational prioritization of deleterious human myelin protein zero gene mutations reveals structural disruption and potential myelin dysfunction through dynamic simulations and stability analysis.

Abstract excerpt

The MPZ (Myelin Protein Zero) gene, located on chromosome 1q23.3, plays a crucial role in myelin sheath formation and maintenance. Mutations in the MPZ protein are linked to demyelinating neuropathies, yet the structural and functional consequences of these mutations remain unclear. This study aims to identify and analyze the impact of nonsynonymous single nucleotide polymorphisms (nsSNPs) on the structure and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computational Biology
• Share to Molecular Dynamics Simulation