Article

A physiologically based pharmacokinetic model for CYP2E1 phenotyping via chlorzoxazone

2023-04-14

Abstract excerpt

<h4>ABSTRACT</h4> The cytochrome P450 (CYP) superfamily of enzymes plays a critical role in the metabolism of drugs, toxins, and endogenous and exogenous compounds. The activity of CYP enzymes can be influenced by a variety of factors, including genetics, diet, age, environmental factors, and disease. Among the major isoforms, CYP2E1 is of particular interest due to its involvement in the metabolism of various lo...

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Literature Corpus work: 57a0d7ab-f851-55f2-be44-7a8470cd0943
DOI: 10.1101/2023.04.12.536571

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