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Article

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.

Cancer cell - 9 Apr 2018

Liu Yang, Sethi Nilay S, Hinoue Toshinori, Schneider Barbara G, Cherniack Andrew D, Sanchez-Vega Francisco, Seoane Jose A, Farshidfar Farshad, Bowlby Reanne, Islam Mirazul, Kim Jaegil, Chatila Walid, Akbani Rehan, Kanchi Rupa S, Rabkin Charles S, Willis Joseph E, Wang Kenneth K, McCall Shannon J, Mishra Lopa, Ojesina Akinyemi I, Bullman Susan, Pedamallu Chandra Sekhar, Lazar Alexander J, Sakai Ryo, Thorsson Vésteinn, Bass Adam J, Laird Peter W

Abstract excerpt

We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and comprised those enriched for insertions/deletions, representing microsatellite instability cases with epigenetic silencing of MLH1 in the context of CpG island...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29622466
DOI: 10.1016/j.ccell.2018.03.010
PMCID: PMC5966039

Genes

KRAS
MLH1
PCBP1
POLE
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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