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Article

Genomic Profiling of Small Intestine Cancers From a Real-World Data Set Identifies Subgroups With Actionable Alterations.

JCO precision oncology - 1 Aug 2024

Takeda Hiroyuki, Yamamoto Hiroyuki, Oikawa Ritsuko, Umemoto Kumiko, Arai Hiroyuki, Mizukami Takuro, Ogawa Kazuki, Uchida Yoshiyasu, Nagata Yusuke, Kubota Yohei, Doi Ayako, Horie Yoshiki, Ogura Takashi, Izawa Naoki, Moore Jay A, Sokol Ethan S, Sunakawa Yu

Abstract excerpt

PURPOSE: Panel-based comprehensive genomic profiling (CGP) is used in clinical practice worldwide; however, large real-world data (RWD) of patients with advanced small intestine cancer have not been characterized. We investigated differences in the prevalence of clinically relevant alterations across molecularly defined or age-stratified subgroups. PATIENTS AND METHODS: This was a collaborative biomarker study of...

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Source

Identifiers

PMID: 39116356
DOI: 10.1200/PO.23.00425

Genes

APC
KRAS
BRAF
BRCA1
BRCA2
CCND1
CDKN2A
ERBB2
GATA6
MDM2
MYC
NTRK1
TP53

Variants

Provenance

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