Article
Genetic Profiling of Cancers of the Digestive System: Biological Insights and Clinical Implications.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2017
Stenzinger Albrecht, Weichert Wilko
Abstract excerpt
Massive parallel sequencing technologies (next-generation sequencing) have enabled us to draw a comprehensive landscape of the genomic aberrations underlying common cancers of the digestive system, and they have thus revolutionized our understanding of the genomic makeup and biology of these tumors. Apart from the commonly mutated founder genes, e.g., KRAS and TP53, we now have detailed information on additional...
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