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Article

The Potential Transcriptomic and Metabolomic Mechanisms of ATO and ATRA in Treatment of FLT3-ITD Acute Myeloid Leukemia.

Technology in cancer research & treatment - 1 Jan 2000

Peng Chun-Jin, Fan Zhong, Luo Jie-Si, Wang Li-Na, Li Yu, Liang Cong, Zhang Xiao-Li, Luo Xue-Qun, Huang Li-Bin, Tang Yan-Lai

Abstract excerpt

BACKGROUND: Acute myeloid leukemia (AML) with Fms-like tyrosine kinase 3 gene internal tandem duplication (FLT3-ITD) mutations has a poor prognosis. The combination of arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) has a synergistic killing effect on leukemia cells with FLT3-ITD mutation. However, the mechanism, especially the changes of gene expression and metabolic activity remain unclear. Here we...

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Identifiers

PMID: 38179723
DOI: 10.1177/15330338231223080
PMCID: PMC10771057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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