Article
DNA-damage response in hematopoietic stem cells: an evolutionary trade-off between blood regeneration and leukemia suppression
30 Jan 2017
Abstract excerpt
Self-renewing and multipotent hematopoietic stem cells (HSCs) maintain lifelong hematopoiesis. Their enormous regenerative potential coupled with lifetime persistence in the body, in contrast with the Progenitors, demand tight control of HSCs genome stability. Indeed, failure to accurately repair DNA damage in HSCs is associated with bone marrow failure and accelerated leukemogenesis. Recent observations exposed...
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