Article

Accelerated Hematopoietic Stem Cell Aging in Space

2024-02-01

Abstract excerpt

Stem cell aging is accelerated by macroenvironmental and microenvironmental stressors, including inflammation. Previously, the NASA Twins study revealed inflammatory cytokine upregulation, chromosomal alterations, and telomere changes suggestive of accelerated aging in low-Earth orbit (LEO). To investigate the effects of spaceflight on human hematopoietic stem and progenitor cell (HSPC) aging, the NASA-supported I...

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Literature Corpus work: 1ef60d7e-1887-57ec-b170-9067846c0b28
DOI: 10.1101/2024.01.28.577076

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