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Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis

24 Oct 2024

Abstract excerpt

Hematopoietic stem cells (HSCs) and erythropoiesis are activated during pregnancy and after bleeding by the derepression of retrotransposons, including endogenous retroviruses and long interspersed nuclear elements. Retrotransposon transcription activates the innate immune sensors cyclic guanosine 3',5'-monophosphate-adenosine 5'-monophosphate synthase (cGAS) and stimulator of interferon (IFN) genes (STING),...

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PMID: 39446896
DOI: 10.1126/science.ado6836

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