Article
Use of the Ion AmpliSeq Cancer Hotspot Panel in clinical molecular pathology laboratories for analysis of solid tumours: With emphasis on validation with relevant single molecular pathology tests and the Oncomine Focus Assay.
Pathology, research and practice - 1 May 2018
Lee Ahwon, Lee Sung-Hak, Jung Chan Kwon, Park Gyungsin, Lee Kyo Young, Choi Hyun Joo, Min Ki Ouk, Kim Tae Jung, Lee Eun Jung, Lee Youn Soo
Abstract excerpt
Targeted application of next-generation sequencing (NGS) technology allows detection of specific mutations that can provide treatment opportunities for cancer patients. We evaluated the applicability of the Ion AmpliSeq Cancer Hotspot Panel V2 (CHV2) using formalin-fixed, paraffin-embedded (FFPE) tissue of clinical specimens. Thirty-five FFPE tumour samples with known mutational status were collected from four...
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