Article
Comparison of Next-Generation Sequencing Panels and Platforms for Detection and Verification of Somatic Tumor Variants for Clinical Diagnostics.
The Journal of molecular diagnostics : JMD - 1 Nov 2016
Misyura Maksym, Zhang Tong, Sukhai Mahadeo A, Thomas Mariam, Garg Swati, Kamel-Reid Suzanne, Stockley Tracy L
Abstract excerpt
Use of next-generation sequencing to detect somatic variants in DNA extracted from formalin-fixed, paraffin-embedded tumor tissues poses a challenge for clinical molecular diagnostic laboratories because of variable DNA quality and quantity, and the potential to detect low allele frequency somatic variants difficult to verify by non-next-generation sequencing methods. We evaluated somatic variant detection...
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