Article
Technical feasibility of a long read, fourth generation sequencing platform in diagnostic profiling of clinical routine samples: a proof-of-concept study.
Pathologica - 1 Apr 2026
Vitale Domenico, Colarossi Lorenzo, Russo Gianluca, Scimone Claudia, Cozzolino Domenico, De Luca Caterina, Prjibelski Andrey D, Mikheenko Alla, Colarossi Cristina, Delli Muti Francesco, Pepe Francesco, Memeo Lorenzo, Troncone Giancarlo, Muscarella Lucia Anna, Malapelle Umberto
Abstract excerpt
Background: Next generation sequencing (NGS) impacted on clinical algorithm of solid tumor patients. A heterogeneous series of NGS platforms have been implemented in clinical practice but challenging handling procedures, high technical costs, and scant affordability on sequencing diagnostic routine specimens can leave behind some patients who could benefit from target drugs. Here, we sought to evaluate technical...
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