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Article

A Targeted High-Throughput Next-Generation Sequencing Panel for Clinical Screening of Mutations, Gene Amplifications, and Fusions in Solid Tumors.

The Journal of molecular diagnostics : JMD - 1 Mar 2017

Luthra Rajyalakshmi, Patel Keyur P, Routbort Mark J, Broaddus Russell R, Yau Jonathan, Simien Crystal, Chen Wei, Hatfield David Z, Medeiros L Jeffrey, Singh Rajesh R

Abstract excerpt

Clinical next-generation sequencing (NGS) assay choice requires careful consideration of panel size, inclusion of appropriate markers, ability to detect multiple genomic aberration types, compatibility with low quality and quantity of nucleic acids, and work flow feasibility. Herein, in a high-volume clinical molecular diagnostic laboratory, we have validated a targeted high-multiplex PCR-based NGS panel...

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Identifiers

PMID: 28017569
DOI: 10.1016/j.jmoldx.2016.09.011

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