Article
Versatile ion S5XL sequencer for targeted next generation sequencing of solid tumors in a clinical laboratory.
PloS one - 1 Jan 2017
Mehrotra Meenakshi, Duose Dzifa Yawa, Singh Rajesh R, Barkoh Bedia A, Manekia Jawad, Harmon Michael A, Patel Keyur P, Routbort Mark J, Medeiros L Jeffrey, Wistuba Ignacio I, Luthra Rajyalakshmi
Abstract excerpt
BACKGROUND: Next generation sequencing based tumor tissue genotyping involves complex workflow and a relatively longer turnaround time. Semiconductor based next generation platforms varied from low throughput Ion PGM to high throughput Ion Proton and Ion S5XL sequencer. In this study, we compared Ion PGM and Ion Proton, with a new Ion S5XL NGS system for workflow scalability, analytical sensitivity and...
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