Article
Routine use of the Ion Torrent AmpliSeq™ Cancer Hotspot Panel for identification of clinically actionable somatic mutations.
Clinical chemistry and laboratory medicine - 1 May 2014
Tsongalis Gregory J, Peterson Jason D, de Abreu Francine B, Tunkey Christopher D, Gallagher Torrey L, Strausbaugh Linda D, Wells Wendy A, Amos Christopher I
Abstract excerpt
BACKGROUND: Somatic mutation analysis is standard of practice for solid tumors in order to identify therapeutic sensitizing and resistance mutations. Our laboratory routinely performed standalone PCR-based methods for mutations in several genes. Rapid discovery and introduction of new therapeutics has demanded additional genomic information for adequate management of the cancer patient. We evaluated a next...
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