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Article

New Developments in the Genetics of Inclusion Body Myositis.

Current rheumatology reports - 2 Apr 2018

Britson Kyla A, Yang Stephanie Y, Lloyd Thomas E

Abstract excerpt

PURPOSE OF REVIEW: Our goal is to review the recent literature pertaining to the genetics of sporadic inclusion body myositis (IBM). RECENT FINDINGS: In a study of 252 IBM patients, the class II MHC allele HLA-DRB1*03:01 showed the most significant association with IBM, and that risk could be largely attributed to amino acids within the peptide-binding pocket. Candidate gene sequencing identified rare missense...

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Topics

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Share to SQSTM1 gene
Share to Genetic Predisposition to Disease
Share to Genetic Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA Antigens

Share to HLA-DRB1 Chains

Share to Mitochondria, Muscle

Share to Myositis, Inclusion Body

Share to Proteostasis

Source

Open in PubMed Open full text

Identifiers

PMID: 29611059
DOI: 10.1007/s11926-018-0738-0
PMCID: PMC6374100

Genes

FYCO1
SQSTM1
VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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