Article
Proteomics of rimmed vacuoles define new risk allele in inclusion body myositis.
Annals of neurology - 1 Feb 2017
Güttsches Anne-Katrin, Brady Stefen, Krause Kathryn, Maerkens Alexandra, Uszkoreit Julian, Eisenacher Martin, Schreiner Anja, Galozzi Sara, Mertens-Rill Janine, Tegenthoff Martin, Holton Janice L, Harms Matthew B, Lloyd Thomas E, Vorgerd Matthias, Weihl Conrad C, Marcus Katrin, Kley Rudolf A
Abstract excerpt
OBJECTIVE: Sporadic inclusion body myositis (sIBM) pathogenesis is unknown; however, rimmed vacuoles (RVs) are a constant feature. We propose to identify proteins that accumulate within RVs. METHODS: RVs and intact myofibers were laser microdissected from skeletal muscle of 18 sIBM patients and analyzed by a sensitive mass spectrometry approach using label-free spectral count-based relative protein...
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