Genetic advances in sporadic inclusion body myositis.

doi:10.1097/BOR.0000000000000213

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Article

Genetic advances in sporadic inclusion body myositis.

Current opinion in rheumatology - 1 Nov 2015

Gang Qiang, Bettencourt Conceição, Houlden Henry, Hanna Michael G, Machado Pedro M

Abstract excerpt

PURPOSE OF REVIEW: To describe recent developments in the genetics of sporadic inclusion body myositis (sIBM). RECENT FINDINGS: Genes located within major histocompatibility complex regions remain the strongest genetic association with sIBM. The rs10527454 polymorphism in the TOMM40 gene seems to have a disease modifying effect on sIBM by delaying the onset of symptoms, and this effect may be enhanced by the APOE...

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Identifiers

PMID: 26335925
DOI: 10.1097/BOR.0000000000000213

Genes

APOE
SQSTM1
TOMM40
VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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