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Article

Identification and Characterization of Positively Selected Mutations in Nef of Four HIV-1 Major Subtypes from Los Alamos National Laboratory.

Current HIV research - 1 Jan 2018

Shadabi Elnaz, Liang Binhua, Plummer Frank, Luo Ma

Abstract excerpt

BACKGROUND: Human immunodeficiency virus-1 (HIV-1) mutates rapidly to escape host immune pressure. This results in the generation of positively selected mutations (PSM) throughout the viral genome. Escape mutations in Nef, one of the accessory proteins of HIV-1, which plays an important role in viral pathogenicity have previously been identified in several large cohort studies, but the evolution of PSMs overtime...

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Share to Amino Acid Substitution
Share to Databases, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to HIV Infections

Share to nef Gene Products, Human Immunodeficiency Virus

Share to Selection, Genetic

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 29600767
DOI: 10.2174/1570162X16666180330140807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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