Structural Features and Genetic Diversity in Gag Gene of Rare HIV-1 Subtypes from the Democratic Republic of Congo.

doi:10.1089/AID.2022.0154

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Article

Structural Features and Genetic Diversity in Gag Gene of Rare HIV-1 Subtypes from the Democratic Republic of Congo.

AIDS research and human retroviruses - 1 Mar 2024

Godwe Célestin, Vidal Nicole, Muwonga Jérémie, Butel Christelle, Serrano Laetitia, Edidi Samuel, Ahuka-Mundeke Steve, Koro Koro Francioli, Etoa Xavier, Tongo Marcel, Peeters Martine, Ayouba Ahidjo

Abstract excerpt

Type-1 HIV (HIV-1) group M (HIV-1M) genetic diversity is highest in the Congo Basin where the epidemic ignited a century ago. HIV-1M has diversified into multiple subtypes, sub-subtypes, and circulating and unique recombinant forms (CRFs/URFs). An unanswered question is why some rare subtypes never reached epidemic levels despite their age. Several studies identified the role of HIV-1M accessory genes nef and vpu...

Topics

Humans
Democratic Republic of the Congo
Phylogeny
HIV-1
Genes, gag
HIV Infections
HIV Seropositivity
Genetic Variation

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Identifiers

PMID: 37335033
DOI: 10.1089/AID.2022.0154

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